ABSTRACT
It has been reported that, compared with simple increased nuchal translucency, fetal cases with septated cystic hygroma (CH) are more likely to face perinatal handicaps. However, pediatric outcomes and proper prenatal counseling for this anomaly have not yet been truly defined. We performed this study to determine pregnancy and pediatric outcomes of fetuses with septated CH. We searched records for cases with septated CH and collected data for structural abnormalities, karyotype analysis, and pregnancy outcomes. Fetuses born with septated CH were also evaluated for their pediatric outcomes. Sixty-nine fetuses with septated CH were enrolled in the study. Results showed that chromosomal abnormalities were present in 28 fetuses (40.6%), and the most common aneuploidy was Turner syndrome (n=14, 20.3%); 16 (23.2%) of the remaining cases, in which aneuploidy was not found, had coexistent structural malformations; 25 (36.2%) cases had normal karyotype and morphology. The total number of live births and infants with unfavorable neurologic follow-up were 13 (18.8%) and 2 (2.9%), respectively. Septated CH is associated with poor perinatal outcomes; therefore, karyotype analysis and ultrasonographic anomaly screening should be performed as initial steps, and expectant management should be offered to couples with euploid fetuses that have normal morphology.
Subject(s)
Female , Humans , Pregnancy , Chromosome Aberrations , Hydrops Fetalis/genetics , Hydrops Fetalis , Lymphangioma, Cystic/genetics , Lymphangioma, Cystic , Aneuploidy , Fetal Death/etiology , Hydrops Fetalis/epidemiology , Karyotype , Karyotyping , Lymphangioma, Cystic/complications , Lymphangioma, Cystic/epidemiology , Pregnancy Outcome , Prenatal Diagnosis , Prognosis , Retrospective Studies , Turkey/epidemiology , Ultrasonography, PrenatalSubject(s)
Humans , Female , Pregnancy , Chromosome Aberrations , Ultrasonography/statistics & numerical data , Biometry , Extremities/abnormalities , Hernia, Umbilical , Hernia, Umbilical/genetics , Jaw Abnormalities , Jaw Abnormalities/genetics , Lymphangioma, Cystic/genetics , Lymphangioma, CysticABSTRACT
Se presenta una serie de 9 casos de higroma quístico, cuyo diagnóstico ultrasonográfico perinatal se realizó entre la semana 14 y 28 de gestación. Siete de los nueve casos estudiados, presentaban cromosomopatías agregada, constituyendo el Síndrome de Turner el hallazgo mas frecuente. El pronóstico de ésta alteración depende de su asociación con cromosomopatías, del tamaño y/o tabicamiento de las formaciones quísticas, de la presencia de hidrops fetal y de la existencia de otras malformaciones agregadas. Nuestra experiencia es absolutamente concordante o coincidente con la literatura mundial